Investigation of gadolinium doped manganese nano spinel ferrites via magnetic hypothermia therapy effect towards MCF-7 breast cancer

• DOI: 10.1016/j.heliyon.2024.e24792
• Publication Date: 2024-01-19T13:03:55Z
• Authors: M. Tahir; M. Fakhar-e-Alam; Muhammad Asif; M. Javaid Iqbal; Aoun Abbas; Mudassir Hassan; Javed Rehman; Qaisar Abbas Bhatti; Ghulam Mustafa; Asma A. Alothman; Saikh Mohammad
• Keywords: Social sciences (General); H1-99; Magnetic spinal ferrites; VSM and MCF-7; Q1-390; Science (General); 02 engineering and technology; 0210 nano-technology; Magnetic hyperthermia therapy; MRI; Research Article

Magnetic spinel ferrite nanoparticles (MSF-NPs) are potential candidates for biomedical applications, especially in cancer diagnosis and therapy due to their excellent physiochemical and magnetic properties. In the current study, MSF-NPs were fabricated by sol-gel auto combustion method. The crystal structure and surface morphology were confirmed by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The magnetic properties were studied by VSM (vibrating sample magnetometer). As increasing Gd3+ concentration, the saturation magnetization values decreased from (17.8-2.3) emu/g, while the coercivity decreased from (499-133) Oe at room temperature. Finally, the fabricated MSF-NPs were tested against anticancer activity by MTT assay. The IC50 = 21.27 μg/mL value was observed, showing the strong antiproliferative activity of these nanoparticles. These results suggested that the obtained MSF-NPs would be useful for remote-controlled hyperthermia therapy for cancer treatment and MRI application due to their excellent magnetic properties. These distinct properties make MSF-NPs most suitable for cancer treatment and bright Contrast Agents (T1-MRI).