Metabolomics study of graphene nuangong acupoint plaster for primary dysmenorrhea

• DOI: 10.1016/j.heliyon.2024.e25268
• Publication Date: 2024-02-01T18:03:31Z
• Authors: Wu Liu; Ting Zhang; Zhaoduan Hu; Xin Li; Fuchun Wang; Rui Peng
• Keywords: Social sciences (General); H1-99; 0301 basic medicine; Q1-390; 03 medical and health sciences; Science (General); Graphene nuangong acupoint plaster; Metabolomics; Primary dysmenorrhea; Research Article

Primary dysmenorrhea is a common gynecological disease with typical clinical symptoms and diverse treatment methods. Acupoint patch therapy one of the traditional external treatments Chinese medicine, long history, has been widely used in many diseases China. Graphene nuangong acupoint plaster (GNGAP) developed based on acupoints new materials have primary dysmenorrhea, satisfactory therapeutic effects achieved. However, underlying mechanisms GNGAP still need further investigation. In this study, we estradiol benzoate combined oxytocin intraperitoneally to establish model rats, observed torsion response, uterine organ coefficients, prostaglandin levels metabolite changes rats after intervention GNGAP, elucidate mechanism effect GNGAP. Compared normal exhibited increased writhing response latency time, coefficient, significant 79 metabolites. Twenty-three significantly enriched pathways were discovered, including amino acid metabolism, arachidonic pyrimidine ovarian steroidogenesis, which may be involved pathogenesis dysmenorrhea. group, time coefficient group improved, nine metabolites altered, among such as 4-pyridoxic acid, d-glucarate Phenol identified potential biomarkers for Vitamin B6 Ascorbate aldarate metabolism Tyrosine metabolic pathways. These findings contribute screening study pathological Additionally, they reveal biological at level.