Hydroxyapatite and cellulose nanocrystals loaded gelatin-chitosan based electrospun nanofibrous mats for rapid wound healing

• DOI: 10.1016/j.heliyon.2024.e25871
• Publication Date: 2024-02-07T16:59:08Z
• Authors: Mobashsara Tabassum; Md. Shahruzzaman; Nasima Akter Mukta; Shanta Biswas; M. Nuruzzaman Khan; Md. Abdul Kader; Papia Haque
• Keywords: Gelatin; Electrospinning; Biomaterial

Electrospinning of a heterogeneous solution is difficult to continue because the required process parameters are different for multiple phases. In this study, nanofibrous mats were successfully prepared from blend solid cellulose nanocrystals (CNC) and hydroxyapatite nanoparticles (HAp) in mixture chitosan gelatin using an electrospinning technique. HAp CNC used as filler materials mats. Gelatin polymer chains crosslinked glutaraldehyde. The fiber diameter was noticed decrease around 86 43 nm with increase electrical conductivity spinning 890 1166 μS cm−1 after crosslinking significant variation fibers' noticed. elemental analysis data showed that 85% passed through nozzle rest portion remained settled syringe. XRD crystallinity chitosan, not observed non-crosslinked TGA mat has no weight retention at 500 °C which due its complete amorphous nature. single-phase transition temperatures DSC proves segregation present electrospun fibers. FTIR new peak 1205 suggests Michael addition type reactions be happened between gelatin. Cytotoxicity on vero-cell line 95% cell viability. applied wound dressings mice model experiment 50% faster healing wounds than control one.