The association between high mobility group box 1 (HMGB1) and Interleukin-18 (IL-18) serum concentrations in COVID-19 inpatients

• DOI: 10.1016/j.heliyon.2024.e26619
• Publication Date: 2024-02-20T07:51:11Z
• Authors: Sri Wulandari; Titik Nuryastuti; Farida Nur Oktoviani; Marselinus Edwin ...; Endah Supriyati; Eggi Arguni; Hartono; Tri Wibawa
• Keywords: HMGB1; High-mobility group; 2019-20 coronavirus outbreak

BackgroundHigh mobility group box 1 (HMGB1) and interleukin-18 (IL-18) are involved in various non-coronavirus disease pathogenesis reported as potential biomarkers for coronavirus (COVID-19). However, their association with COVID-19 has not yet been explored.AimThis study aimed to investigate the between HMGB1 IL-18 concentrations sera of patients versus non-COVID-19 patients.Material methodsWe used stored serum samples obtained from 30 patients. We collected data on age, gender, treatment status, principal diagnosis, comorbidity patient medical records. were analyzed by enzyme-linked immunosorbent assay (ELISA). The swab samples' RT-PCR cycle threshold (CT) values laboratory database.ResultsHMGB1 increased inpatients compared outpatients (COVID-19 vs. outpatients: 151.33 (90.27–192.38) 80.75 (54.16–128.72) ng/ml; p = 0.0316; 152.66 (104.04–288.51) 0.0199). also higher 620.00 (461.50–849.6) 403.10 (372.70–556.90) pg/ml; 0.0376; 835.70 (558.30–1602.00) 0.0026). Moreover, was associated (p 0.0337; r 0.5500).ConclusionThe might indicate a dangerous leading cytokine storm occur.