Novel therapeutic role of Ganoderma Polysaccharides in a septic mouse model - The key role of macrophages

• DOI: 10.1016/j.heliyon.2024.e26732
• Publication Date: 2024-02-20T21:04:32Z
• Authors: Wei Xiong; Jing Xia; Xiaoyuan Peng; Ying Tan; Wansong Chen; Minghua Zhou; Ce Yang; Wenxiang Wang
• Keywords: H1-99; 0301 basic medicine; Science (General); Regulatory T lymphocytes; Macrophages; Immunopathology; Social sciences (General); Q1-390; 03 medical and health sciences; Sepsis; Ganoderma lucidum polysaccharides; Cytokines; Research Article

Ganoderma lucidum polysaccharides (G. PS) have been recognized for their immune-modulating properties. In this study, we investigated the impact of G. PS in a sepsis mouse model, exploring its effects on survival, inflammatory cytokines, Treg cell differentiation, bacterial load, organ dysfunction, and related pathways. We also probed role macrophages through chlorphosphon-liposome pretreatment. Using cecal ligation puncture (CLP) categorized mice into normal, PBS, injection groups. significantly enhanced septic regulated cytokines (TNF-α, IL-17A, IL-6, IL-10), promoted CD4+Foxp3+ differentiation spleens. Additionally, reduced mitigated damage, suppressed NF-κB pathway. vitro, facilitated CD4