Assessment of adherence to carbamazepine using plasma and saliva samples, a study from Jordan

• DOI: 10.1016/j.heliyon.2024.e26736
• Publication Date: 2024-02-23T08:38:18Z
• Authors: Ghaith M. Al-Taani; Alaa Yehya; Dima Albals; Mervat Alsous
• Keywords: Pharmacology; Social sciences (General); H1-99; Q1-390; 03 medical and health sciences; Carbamazepine; Jordan; Science (General); 0302 clinical medicine; Adherence; Compliance; Research Article

BackgroundThe measurement of carbamazepine levels in a biological sample is required to guide dosing, and prevent toxicity, can be useful assess medication adherence.AimThe primary aim the presented study analyze saliva plasma samples outpatients adherence using levels.MethodsAdults who used for at least one month were recruited from outpatient clinic department Princess Basma Hospital, public hospital Irbid. Saliva blood (1 ml) collected simultaneously subjects, microanalytical method with high-performance liquid chromatography coupled an ultraviolet detector, level (in micrograms per milliliter) was ascertained. Analysis carried out levels.ResultsA total 69 consecutive patients attending neurology recruited, whom 85.5% had epilepsy. Approximately one-third (34.8%) as monotherapy, whereas remainder combination antiepileptic drugs control seizures. Overall, about two-thirds (71.9%) studied non-adherent either or samples. By referring concentration, 75.4% respondents adherents, 15.9% under-adherence, 8.7% over-adherence. A 85.9% responders adherent Plasma linearly correlated another. Polypharmacy commonly utilized patients, 42% two medications, range 1–7 concomitantly. The predictor associated higher levels, determined by multiple linear regression analysis, occurrence seizures less than once month, compared frequencies.ConclusionSaliva show potential alternative matrix adherence, considerable correlation level. Healthcare professionals address routine care non-adherence through such measures.