Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative Stress, preventing inflammation and apoptosis: Ultrastructural and computational approaches

• DOI: 10.1016/j.heliyon.2024.e27164
• Publication Date: 2024-02-27T04:35:39Z
• Authors: Ayed A. Shati; Refaat A. Eid; Attalla F. El-kott; Youssef A. Alqahtani; Abdullah S. Shatoor; Mohamed Samir Ahm...
• Keywords: Cardiotoxicity

Currently, doxorubicin (DOX) is one of the medications commonly used in chemotherapy to treat different types tumors.Nonetheless, despite being effective multiple tumors, yet its use limited owing cytotoxic effects, therapeutic DOX has been limited. This work aimed explore whether curcumin (CMN) can prevents DOX-induced cardiotoxicity rats. Four groups rats were created, with first functioning as a control, while second group received CMN. alone was administered third group, whereas CMN and fourth group. Lipid peroxidation assessed Malondialdehyde (MDA), aspartate aminotransferase (AST), alanine (ALT), oxidative stress markers catalase (CAT), superoxide dismutase (SOD), inflammatory tumor necrosis factor-alpha (TNF-α) heart homogenates, each assessed. Heart specimens investigated histologically ultrastructurally. Increased, AST, ALT serum levels, increased MDA decreased SOD CAT TNF-α concentrations homogenates all signs myocardial injury. Histological ultrastructural examinations revealed vacuoles larger, swollen mitochondria cytoplasm. Furthermore, caused significant changes myocardium, most notably nuclei disintegration, myofibrillar loss, myocyte vacuolization. Using reduced harmful consequences on myocardium by returning AST levels their original compared control reducing them. In cardiac tissue, significantly TNF-α. Biochemical histological studies have demonstrated that heart-protective effect might be related antioxidant anti-inflammatory capabilities.