Exercise capacity-hemodynamics mismatch in elderly patients with pulmonary hypertension: A nationwide multicenter study from Taiwan Society of Cardiology Pulmonary Hypertension Registry (TAIPANS)

• DOI: 10.1016/j.heliyon.2024.e27537
• Publication Date: 2024-03-11T09:57:07Z
• Authors: Chang-Ying Chen; Wang Mei-Tzu; Shih-Hsien Sung; Yih-Jer Wu; Chih-Hsin Hsu; Wan-Jing Ho; Yen-Hung Lin; Wei-Shin Liu; Ju-Chi Liu; Yung-Ta Kao; Wen-Shiann Wu; Chun-Hsien Wu; Meng-Huan Lei; Yu-Wei Chen; Chien Chen-Yu; Yu-Wei Chiu; Zen-Kong Dai; Tsung-Hsien Lin; Lin Lin; Cheng-Chih Chung; Chang-Min Chung; Sung-Hao Huang; Chin-Chang Cheng; Yen-Wen Wu; Ting-Hsing Chao; Juey-Jen Hwang; Charles Jia-Yin Hou; Wei-Chun Huang
• Keywords: Social sciences (General); H1-99; Q1-390; 03 medical and health sciences; Elderly; Science (General); 0302 clinical medicine; Hemodynamic; Pulmonary hypertension; Research Article

BackgroundDemographics of pulmonary hypertension (PH) has changed a lot over the past forty years. Several recent registries noted an increase in mean age PH but only few them investigated characteristics elderly patients. Thus, we aimed to analyze such population this study.MethodsThis multicenter study enrolled patients diagnosed with group 1, 3, 4, and 5 consecutively from January 2019 December 31, 2020. A total 490 was included, were divided into three groups by (≤45 years, 45–65 >65 years).ResultsThe 55.3 ± 16.3 years age. There higher proportion classified as 3 (≤45: 1.3, 45–65: 4.5, >65: 8.1 %; p = 0.0206) 4 8.4, 14.5, 31.6 < 0.0001) than young Elderly had shorter 6-min walking distance (6 MWD) vs. >65, difference, 77.8 m [95% confidence interval (CI), 2.1–153.6 m]), lower arterial pressure (mPAP) 10.8 mmHg CI, 6.37–15.2 mmHg]), wedge (PAWP) 45–65, −2.1 −3.9 −0.3 mmHg]) compared poorer exercise capacity despite mPAP level population, they received combination therapy less frequently (triple 1 PH, ≤45: 16.7, 11.3, 3.8 0.0005). Age older 65 independent predictor high mortality for patients.ConclusionsElderly possess unique hemodynamic profiles epidemiologic patterns. They PAWP, mPAP, frequently. Moreover, ageing is Exercise capacity-hemodynamics mismatch inadequate treatment are noteworthy approach PH.