Neuroprotective effects of dendrobium endophytes metabolites in SH-SY5Y cells via the Nrf2/Keap1 pathway

• DOI: 10.1016/j.heliyon.2024.e28222
• Publication Date: 2024-03-18T17:07:06Z
• Authors: Yan tian Liang; Jia meng Liu; Lu qi Qin; Cong Lu; Jing Sun; Qiong Wang; Yong Yang; Bei Fan; Feng zhong Wang
• Keywords: SH-SY5Y

Recent studies have revealed that endophytes in plants can produce metabolites with activity is comparable to or identical the host. Dendrobine has attracted much attention field of neurodegenerative diseases by exhibiting anti-oxidative stress and neuroprotective effects. This study aimed investigate protective effects mechanisms dendrobium Pseudomonas protegens CM-YJ44 Priestia megaterium D-HT207 against H2O2-induced oxidative injury SH-SY5Y cells. Results showed there were 50 compounds 72 D-HT207. Those both increased significantly cell viability, decreased contents ROS It was confirmed inhibited cells, which mechanism related inhibition production, alteration MMP, apoptosis inflammatory factors expression via Nrf2/Keap1 pathway.