1H-NMR-based urine metabolomics of prostate cancer and benign prostatic hyperplasia

• DOI: 10.1016/j.heliyon.2024.e28949
• Publication Date: 2024-03-31T21:52:12Z
• Authors: Mohammed Zniber; Tarja Lamminen; Pekka Taimen; Peter J. Boström; Tan-Phat Huynh
• Keywords: Overdiagnosis; Rectal examination; Prostatic Diseases

Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are prevalent conditions affecting a significant portion of the male population, particularly with advancing age. Traditional diagnostic methods, such as digital rectal examination (DRE) prostate-specific antigen (PSA) tests, have limitations in specificity sensitivity, leading to potential overdiagnosis unnecessary biopsies.