The critical impacts of cytokine storms in respiratory disorders

• DOI: 10.1016/j.heliyon.2024.e29769
• Publication Date: 2024-04-17T07:50:48Z
• Authors: Shahana Riyaz Tra...; Ahmed M.E. Elkhalifa; Syed Quibtiya; Sofi Imtiyaz Ali; Naveed Nazir Shah; Syed Taifa; Rabia Rakhshan; Iqra Hussain Shah; Muzafar Ahmad Mir; Masood Malik; Zahid Ramzan; Nusrat Bashir; Shubeena Ahad; Ibraq Khursheed; Elsharif A. Bazie; Elsadig Mohamed A...; Abozer Y. Elderdery; Fawaz O. Alenazy; Awadh Alanazi; Badr Alzahrani; Muharib Alruwaili; Emad Manni; Sanaa E. Hussein; Ezeldine K. Abdal...; Showkat Ul Nabi
• Keywords: Cytokine Storm; Case fatality rate; Etiology; Coronavirus

Cytokine storm (CS) refers to the spontaneous dysregulated and hyper-activated inflammatory reaction occurring in various clinical conditions, ranging from microbial infection end-stage organ failure. Recently novel coronavirus involved COVID-19 (Coronavirus disease-19) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has been associated with pathological phenomenon of CS critically ill patients. Furthermore, patients suffering are likely have a grave prognosis higher case fatality rate. Pathologically is manifested as hyper-immune activation clinically multiple An in-depth understanding etiology will enable discovery not just disease risk factors but also therapeutic approaches modulate immune response improve outcomes respiratory diseases having pathogenic pathway. Owing consequences diseases, this attracted attention researchers clinicians throughout globe. So present manuscript, we attempted discuss its ramifications other well prospective treatment biomarkers cytokine storm. provide insight into both prophylactic point view. In addition, included recent findings reported different parts world, which based on expert opinion, case-control research, experimental case-controlled cohort approach.