Plant-derived exosome-like nanovesicles: A novel nanotool for disease therapy

• DOI: 10.1016/j.heliyon.2024.e30630
• Publication Date: 2024-05-03T16:01:56Z
• Authors: Ze Jin; Jintong Na; Xia Lin; Rong Jiao; Xiyu Liu; Yong Huang
• Keywords: Exosome; Extracellular Vesicles

Exosomes are extracellular vesicles comprising bilayer phospholipid membranes and secreted by eukaryotic cells. They released via cellular exocytosis, contain DNA, RNA, proteins, other substances, participate in various communications between tissues organs. Since the discovery of exosomes 1983, animal-derived have become a research focus for small-molecule drug delivery biology, medicine, fields owing to their good biocompatibility homing effects. Recent studies found that plant-derived exosome-like nanovesicles (PELNVs) exhibit certain biological effects, such as anti-inflammatory anti-tumor abilities, minimal toxic side Because they rich active lipid molecules with pharmacological PELNVs could be novel carriers delivery. In this review, formation isolation, extraction PELNVs, well characteristics transporting drugs summarized provide new ideas methods future on nanovesicles.