Influence of apolipoprotein E gene polymorphisms on coronary artery disease in patients undergoing coronary angiography

• DOI: 10.1016/j.heliyon.2024.e33690
• Publication Date: 2024-06-26T07:14:40Z
• Authors: Azhi ShaMa; Yingying Huang; Chunlan Ma; Chunmei Xu; Jingyue Hu; Zhuxin Li; Chunyu Zeng
• Keywords: Apolipoprotein E

ObjectivePrevious studies have shown that apolipoprotein E (ApoE) gene polymorphisms an impact on coronary artery disease(CAD). However, many small sample sizes and different conclusions. The purpose was to retrospectively study the influence of ApoE CAD.MethodsThis assessed genotypes heart disease in patients who received angiography used multivariate logistic regression assess CAD.ResultsPatients with had no obvious differences incidence hypertension, diabetes or obesity(P > 0.05). Patients ε2/ε2 higher hypertriglyceridemia than other genotypes, while ε3/ε3 a lower those ε3/ε4,ε4/ε4, ε2/ε3 ε2/ε2(P < ε3/ε4, ε4/ε4, significant severity CAD (P ε2/ε4 reduced risk high LDL-C, heart(P premature disease(PCAD)(P age <45,age at 60–74 ≥74, ≥74(P 0.05).ConclusionPatients ε4/ε4,ε3/ε3 occurrence CAD. Compared isoform ε3 (ε3/ε3), ε4 did not increased LDL-C