Comparison of adverse events following the second/third dose of BNT162b2 in a medical institute in Japan

• DOI: 10.1016/j.heliyon.2024.e34347
• Publication Date: 2024-07-09T17:41:30Z
• Authors: Takahiro Namiki; Kazuhide Takada; Satoshi Hayakawa; Shihoko Komine-Ai...
• Keywords: H1-99; 0303 health sciences; Science (General); SARS-CoV-2; Lymphadenopathy; COVID-19; Adverse reaction; Social sciences (General); Q1-390; 03 medical and health sciences; Network analysis; Vaccine; Research Article

BackgroundVaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial for ending the pandemic of disease 2019 (COVID-19). Currently, cumulative effect booster shots mRNA vaccines on adverse events is not sufficiently characterized.MethodsA survey-based study vaccine was conducted in a Japanese medical institute after third dose Pfizer BNT162b2. Adverse were grouped using network analysis, and heteroscedastic probit model built to analyse events.ResultsThere two main clusters events, systemic local injection site-associated events. Subject background experience previous vaccine-related variably associated with occurrence intensity following dose. Among only lymphadenopathy increased prominently dose, while largest increase other occurred generally second dose.ConclusionsThe repeated frequency differs depending kind event.