Evolution of neuropeptide Y/RFamide-like receptors in nematodes

• DOI: 10.1016/j.heliyon.2024.e34473
• Publication Date: 2024-07-15T20:02:01Z
• Authors: Franziska Reinhardt; Anette Kaiser; Simone Prömel; Peter F. Stadler
• Keywords: H1-99; 0301 basic medicine; ExonMatchSolver; Science (General); Nematodes; Paralogs; 106025 Neurobiology; Social sciences (General); Q1-390; 03 medical and health sciences; GPCR; 106005 Bioinformatik; Neuropeptide Y/RFamide-like receptors; 106005 Bioinformatics; 106025 Neurobiologie; Research Article

The Neuropeptide Y/RFamide-like receptors belong to the Rhodopsin-like G protein-coupled (GPCRs) and are involved in functions such as locomotion, feeding reproduction. With 41 described they form best-studied group of neuropeptide GPCRs Caenorhabditis elegans. In order understand expansion receptor family nematodes, we started from sequences selected paralogs C. elegans query surveyed corresponding orthologous another 159 representative nematode target genomes. To this end employed a automated pipeline based on ExonMatchSolver, tool that solves paralog-to-contig assignment problem. Utilizing subclass-specific HMMs were able detect total 1557 (1100 NPRs, 375 FRPRs 82 C09F12.3) genomes investigated here. These demonstrate good conservation across Nematoda highlight diversification evolution. No other genus shares all with Caenorhabditis. At same time, observe large numbers clade specific duplications losses members phylum Nematoda.