Cerebellitis following COVID-19 infection: A case-based systematic review and pooled analysis

• DOI: 10.1016/j.heliyon.2024.e34497
• Publication Date: 2024-07-11T21:59:47Z
• Authors: Soroush Najdaghi; Delaram Narimani ...; Mohammadreza Hash...; Narges Ebrahimi
• Keywords: Cerebellitis; Social sciences (General); H1-99; 0301 basic medicine; Q1-390; 03 medical and health sciences; Science (General); SARS-CoV-2; Systematic review; COVID-19; Cerebellar ataxia; Research Article

BackgroundThe COVID-19 pandemic has been linked to neurological complications, including Cerebellitis. This study aims investigate the clinical features, and consequences of Cerebellitis following infection, informing medical management strategies.MethodsA systematic search was conducted through PubMed, Web Science, Embase, ProQuest, Cochrane databases from January 2018 September 12, 2023, on cases post-COVID-19. Demographics, characteristics, diagnostic techniques were analyzed using descriptive statistics. Chi-Square tests assessed associations between diagnoses treatments, with visualizations heatmaps scatter plots.ResultsAfter final Screening, analysis 18 revealed post-COVID-19 spanned 9 countries, predominantly USA (27.8 %), a mean patient age 40.1 years (±24.6). Males comprised 94.4 % cases. Common underlying conditions included hypertension (22.2 %) diabetes (11.1 %). Neurological symptoms presented average 15.15 ± 12.7 days infection. A moderate negative correlation (r = −0.358) observed symptom onset. Blood CSF biomarkers showed weak correlations onset intervals. Treatment efficacy varied, most achieving symptom-free outcomes. The test for diagnosis-treatment yielded p-value 0.089, follow-up outcomes, 0.283, indicating no significant statistical associations.ConclusionThis review highlights increased reports in males their fourth decade life, highest comorbidities being vascular diseases. Marker assessments show decrease protein half patients, along complete recovery combination treatment antivirals steroids acute