Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities

• DOI: 10.1016/j.heliyon.2024.e34636
• Publication Date: 2024-07-14T10:02:32Z
• Authors: Memoona Ishtiaq; Hina Manzoor; Ikram Ullah Khan; Sajid Asghar; Muhammad Irfan; Norah A. Albekairi; Abdulrahman Alsha...; Abdulrahman F. Al...; Saad Alotaibi; Rabia Munir; Pervaiz A. Shah; Liaqat Hussain; Muhammad Abubakar...; Fizza Abdul Razzaq; Syed Haroon Khalid
• Keywords: Anti-inflammatory agents; H1-99; Curcumin; Science (General); Poloxamer; Social sciences (General); Q1-390; 03 medical and health sciences; 0302 clinical medicine; Solubility; Solid dispersions; Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; Research Article

Amorphous solid dispersion (ASD) has emerged to be an outstanding strategy among multiple options available for improving solubility and consequently biological activity. Interestingly several binary SD systems continue exhibit insufficient over time. Therefore, the goal of current research was design ternary amorphous dispersions (ASDs) hydrophobic model drug curcumin (CUR) enhance dissolution rate in turn, presenting enhanced anti-bacterial, antioxidant anti-inflammatory For this purpose (TSDs) consisting Soluplus®, Syloid® XDP 3150, 244 Poloxamer® 188 combination with HPMC E5 (binary carrier) were prepared using solvent evaporation method. Both testing performed determine increase dissolution. Solid state investigation carried out utilizing infrared spectroscopy, also known as Fourier transform spectroscopy (FTIR), scanning electron microscopy (SEM),Differential calorimetry (DSC) X-ray diffraction (XRD).Optimized formulations tested their effectiveness including anti-oxidant Amid all Ternary F3 entailing 20 % soluplus® remarkably improved (186 μg/ml ± 3.95) (91 3.89 %) by 3100 9 fold respectively. These finding supported FTIR, SEM, XRD DSC. In-vitro antibacterial demonstrated significant improvement activity against both gram positive (