Amentoflavone from Selaginella tamariscina inhibits SARS-CoV-2 RNA-dependent RNA polymerase

• DOI: 10.1016/j.heliyon.2024.e36568
• Publication Date: 2024-08-20T07:13:07Z
• Authors: Kyoung Won Youn; Siyun Lee; Jang Hoon Kim; Yea-In Park; Jaeyeon So; Chansoo Kim; Chong Woon Cho; Junsoo Park
• Keywords: Amentoflavone

Highlights•Selaginella tamariscina extract (STE) inhibits SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) activity.•STE treatment coronavirus replication.•Amentoflavone, a central component of STE, RdRp activity.AbstractThe pandemic caused millions deaths due to its prominent infectivity and mortality. Although the vaccines medicines for are on market, new variants like influenza expected reemerge continuously. Therefore, effective inexpensive will be required respond variants. Here, we used herbal plant extracts search compounds that can interfere with found Selaginella reduce activity. The HCoV-OC43 beta model was examine whether STE could inhibit replication coronavirus-induced cytotoxicity. Next, searched active compound amentoflavone is main STE. Finally, demonstrated replication. Our results collectively indicate from possibly beneficial in responding coronavirus-related diseases, including SARS-CoV-2.