Characteristics and multi-omics analysis of spontaneous spondyloarthritis in non-human primates: Case report

• DOI: 10.1016/j.heliyon.2025.e41706
• Publication Date: 2025-01-08T08:22:33Z
• Authors: Lei Cai; Qing Lv; Ronghua Ma; Wei Liu; Yalun Guan; Zhongqiang Huang; Qingyu Liu; Yunfeng Li; Shuhua Liu; Ge Li; Yu Zhang
• Keywords: KEGG; Proteome; Bone remodeling

Spondyloarthritis is a prevalent and persistent condition that significantly impacts the quality of life. Its intricate pathological mechanisms have led to scarcity animal models capable replicating disease progression in humans, making it prominent area research interest field. To delve into physiological traits spontaneous non-human primate spondyloarthritis, this study meticulously examined features natural model through an array techniques including X-ray imaging, MRI blood biochemistry, markers bone metabolism, transcriptomics, proteomics, metabolomics. imaging results revealed crab-eating monkeys (Macaca fascicularis) with spondyloarthritis developed spurs spine experienced destruction peripheral joints. further confirmed inflammatory changes facet joints these monkeys, along inflammation Blood biochemistry analysis showed abnormalities liver function kidney indicators spondyloarthritis. Analysis metabolism-related decrease formation (BGP) resorption (β-CTx). A thorough correlation was conducted on transcriptome proteome expression data, revealing significant positive between two datasets. total eight genes proteins high levels were identified as common both proteome. Subsequent Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses performed co-expressed proteins, indicating predominant enrichment IL-17 signaling pathway, S100A8 S100A9 core proteins. Further using clinical data conjunction Weighted Co-expression Network (WGCNA) demonstrated phenotypes spinal abnormalities, thereby corroborating close association phenotype Human studies already established link autoimmune-related arthritic diseases, suggesting observed macaques may be related autoimmune diseases. It hypothesized could serve potential predictive biomarkers for primates.