Association of Genetic Variants of the Chemokine Receptor Ccr5 and Its Ligands, Rantes and Mcp–2, With Outcome of Hcv Infection

• DOI: 10.1016/j.hep.2003.09.027
• Publication Date: 2003-11-25T20:29:01Z
• Authors: Simon Hellier; Angela J. Frodsham; Branwen J.W. Hennig; Paul Klenerman; Suzanne Knapp; Patricia Ramaley; Jack Satsangi; Mark Wright; Lyna Zhang; Howard C. Thomas; Mark Thursz; Adrian V.S. Hill
• Keywords: Hepatitis C; CCR2

The effect of host genetic variation on the outcome hepatitis C virus (HCV) infection and its treatment is poorly understood. chemokine receptors CCR5, CCR2, CCR3 their ligands, RANTES, MCP–1, MCP–2, MIP–1α, are involved in immune responses selective recruitment lymphocytes to liver HCV infection. We studied 20 polymorphisms within these genes investigated association with persistent carriage HCV, severity disease, hepatic inflammation, response a large European cohort. Significant associations were found between CCR5–Δ32 reduced portal inflammation ( P = .011, odds ratio [OR]: 2.3, 95% confidence interval [CI]: 1.09–4.84) milder fibrosis .015, OR: 1.97, CI: 1.13–3.42). A promoter polymorphism at position -403 RANTES gene was associated less severe .004). An amino acid change MCP2, Q46K, .018, 2.29, 1.14–4.58). In conclusion, our study suggests possible role CCR5–Δ32, -403, MCP–2 Q46K