Short-term and long-term effects of noninvasive cardiac radioablation for ventricular tachycardia: A single-center case series

• DOI: 10.1016/j.hroo.2022.11.006
• Publication Date: 2022-12-05T18:49:07Z
• Authors: Won Ick Chang; Ha Hye Jo; Myung-Jin Cha; Ji Hyun Chang; Chang Heon Choi; Hak Jae Kim; Seil Oh; Clifford G. Robinson; Phillip S. Cuculich
• Keywords: Single Center; Ischemic Cardiomyopathy

Noninvasive cardiac radioablation is reported to be effective and safe for the treatment of ventricular tachycardia (VT).This study aimed analyze acute long-term effects VT radioablation.Patients with intractable or premature contraction (PVC)-induced cardiomyopathy were included in this treated using a single-fraction 25-Gy dose radioablation. To quantitatively response after treatment, continuous electrocardiography monitoring was performed from 24 hours before 48 irradiation at 1-month follow-up. Long-term clinical safety efficacy assessed 1-year follow-up.From 2019 2020, 6 patients ischemic (n = 3), nonischemic 2), PVC-induced 1). In short-term assessment, total burden beats decreased by 49% within further 70% 1 month. The component earlier more dramatically than PVC (decreased 91% 57% month, respectively). 5 showed complete 3) partial 2) remission arrhythmias. One patient recurrence 10 months, which successfully suppressed medical treatment. posttreatment coupling interval prolonged (+38 ms month). Ischemic markedly radioablation.In small case series patients, without comparison group, appeared decrease burden. A therapeutic effect apparent 1-2 days but variable etiology cardiomyopathy.