Component-specific reduction in perineuronal nets in senescence-accelerated mouse strains

• DOI: 10.1016/j.ibneur.2023.01.002
• Publication Date: 2023-01-16T17:18:42Z
• Authors: Hiroshi Ueno; Yu Takahashi; Shinji Murakami; Kenta Wani; Tetsuji Miyazaki; Yosuke Matsumoto; Motoi Okamoto; Takeshi Ishihara
• Keywords: Perineuronal net; Senescence

With increased life expectancy, age-related diseases are a significant health concern in Western societies. Animal models (e.g., rodents) have been used to understand changes brain function-particularly through the senescence-accelerated mouse (SAM) strain. Previous reports shown that propensity (SAMP)8 and SAMP10 strains learning disabilities. In this study, we analyzed prefrontal cortex, which is involved cognitive function. We aimed clarify parvalbumin-positive interneurons (PV-positive neurons), related function, perineuronal nets (PNNs), special extracellular matrix molecules formed around them. performed histological analysis of PV-positive neurons PNNs cortex elucidate mechanism behavioral abnormalities SAMP8 strains. Expression Cat-315-positive PNN was not confirmed mice. However, density AB1031-positive PNN, tenascin-R-positive brevican-positive decreased mice compared resistance (SAMR1) addition, lower than SAMR1 These mice, exhibited neuropathological phenotypes with age, showed different believe results study will be useful for elucidating mechanisms decline functions using SAM.