Selenium and zinc alleviate quaternary metal mixture -induced neurotoxicity in rats by inhibiting oxidative damage and modulating the expressions of NF-kB and Nrf2/Hmox-1 pathway

• DOI: 10.1016/j.ibneur.2023.06.003
• Publication Date: 2023-06-16T08:04:43Z
• Authors: Chinyere Dike; Chinna N. Orish; Anthonet N. Ezeji...; Ana Cirovic; Aleksandar Cirovic; Bolaji Babatunde; Francis Sikoki; Orish E. Orisakwe
• Keywords: Neurotoxicity; Malondialdehyde

This study evaluated the potential protective effects of Zn and Se in cerebellum cerebral cortex, two fundamentally important brain regions, albino rats that were exposed to heavy metals mixture (Al, Pb, Hg Mn).