Proinflammatory factors inhibition and fish oil treatment: A promising therapy for neonatal seizures

• DOI: 10.1016/j.ibneur.2024.09.006
• Publication Date: 2024-10-02T03:25:28Z
• Authors: Zohreh Ghotbeddin; Nima Badripour; Hossein Amini-Khoei; Zahra Basir; Shima Balali-dehk...
• Keywords: Proinflammatory cytokine

Brain injury is one of the most important causes infant mortality and chronic neurological disabilities. Hypoxia an acute brain which led to various cognitive, behavioral, memory disorders throughout life. Previous studies reported neuroprotective possibilities for fish oil (FO) in brain-injured situations. In this study, we evaluated effect FO diet during lactation period on seizure activity, behavioral performance, histomorphometry, inflammatory changes brains hypoxia rats. Male Wistar rats were randomly divided 4 groups: Sham (intact rats), hypoxia, FO+hypoxia groups. was induced by keeping neonate at PND12 a hypoxic chamber (7 % oxygen 93 nitrogen intensity) 15 minutes. groups, received oral (1 ml/day) 12 days period. Seizure activity assessed measuring number tonic-clonic seizures thresholds. Novel object recognition tests (NORT), rotarod, open field used measure performances. A Histological study performed evaluate histomorphometric hippocampus cerebellum. The gene expression tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β) measured using RT-PCR