Bloodstream infections due to Gram-negative bacteria in patients with hematologic malignancies: updated epidemiology and risk factors for multidrug-resistant strains in an Italian perspective survey

• DOI: 10.1016/j.ijantimicag.2023.106806
• Publication Date: 2023-04-06T06:21:52Z
• Authors: Enrico Maria Trec...; Gabriele Giuliano; Chiara Cattaneo; Stelvio Ballanti; Marianna Criscuolo; Anna Candoni; Francesco Marchesi; Marica Laurino; Michelina Dargenio; Rosa Fanci; Mariagiovanna Cefalo; Mario Delia; Angelica Spolzino; Laura Maracci; Valentina Bonuomo; Alessandro Busca; Maria Ilaria Del ...; Rosa Daffini; Edoardo Simonetti; Giulia Dragonetti; Maria Elena Zannier; Livio Pagano; Mario Tumbarello
• Keywords: Bacteremia

Bloodstream infections (BSI) caused by Gram-negative bacteria (GNB) in patients with hematological malignancies (HM) have been associated high mortality rates, particularly antibiotic-resistant strains. A multicenter cohort study including all consecutive episodes of GNB BSI HM was conducted to update the epidemiology and antibiotic resistance patterns (compared our previous survey between 2009 2012) investigate risk factors for due multidrug-resistant (MDR) isolates. total 834 were recovered 811 from January 2016 December 2018. Compared survey, there a significant reduction use fluoroquinolone prophylaxis recovery susceptibility rates ciprofloxacin among Pseudomonas aeruginosa, Escherichia coli Enterobacter cloacae In addition, shift significantly increased P. aeruginosa isolates ceftazidime, meropenem, gentamicin. 256/834 (30.7%) MDR. multivariable analysis, MDR culture-positive surveillance rectal swabs, therapy aminoglycosides carbapenems, prophylaxis, time at independently BSI. conclusion, despite persistence prevalence GNB, reduced fluoroquinolones almost antibiotics tested isolates, compared survey. Fluoroquinolone colonization independent present study.