The novel drug candidate VOMG kills Mycobacterium abscessus and other pathogens by inhibiting cell division

• DOI: 10.1016/j.ijantimicag.2024.107278
• Publication Date: 2024-07-27T00:41:34Z
• Authors: Giulia Degiacomi; Laurent R. Chiarelli; Olga Riabova; Nicola Ivan Loré; Lara Muñoz-Muñoz; Deborah Recchia; Giovanni Stelitano; Umberto Postiglione; Fabio Saliu; Anna Griego; Viola Camilla Sco...; Elena Kazakova; Edoardo Scarpa; José Manuel Ezque...; Alessandro Stamilla; Silvia Buroni; Enrico Tortoli; Loris Rizzello; Davide Sassera; Santiago Ramón-Ga...; Daniela Maria Cir...; Vadim Makarov; Maria Rosalia Pasca
• Keywords: Mycobacterium abscessus

The incidence of lung infections is increasing worldwide in individuals suffering from cystic fibrosis and chronic obstructive pulmonary diseases. Mycobacterium abscessus associated to deterioration these populations. intrinsic resistance M. most conventional antibiotics jeopardizes treatment success rates. To date no single drug has been developed targeting specifically abscessus. Our objective was characterize the pyrithione-core drug-like small molecule named VOMG as a new compound active against other pathogens. We used multidisciplinary approach including microbiological, chemical, biochemical transcriptomics procedures validate promising anti-M. candidate. report for first time vitro vivo bactericidal activity Besides being biofilm, showed favourable pharmacology (ADME-Tox) profile. Frequency studies were unable isolate resistant mutants. inhibits cell division, particularly FtsZ enzyme. discovered inhibiting division with broad spectrum microbial