The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf – a preliminary clinical investigation

• DOI: 10.1016/j.ijat.2003.12.005
• Publication Date: 2004-03-25T13:59:20Z
• Authors: L Orafidiya
• Keywords: Aloe Vera; Ocimum gratissimum; Lotion

Abstract Aim: This study was designed to investigate possible synergistic effect of aloe vera gel on the anti-acne properties of Ocimum gratissimum oil and to compare the activities of both agents singly and in combinations with the anti-acne agent Dalacin™ – a 1% Clindamycin phosphate solution. Methods: 84 subjects presenting with clinically significant Acne vulgaris (mainly undergraduates of a University) were randomly assigned into seven groups and treated with different test preparations (2% v/v Ocimum oil lotion containing graded concentrations (0–≈100%) of aloe gel, placebo or control preparations). Samples tested were applied to the face after washing morning and evening. The numbers of inflammatory lesions (papules and pustules) were counted prior to application and daily for 4 weeks. The efficacy of the preparations was rated in terms of product activity (1/D), which is the reciprocal value of the number of days taken to achieve 50% reduction in lesion count. Results: The efficacy of the Ocimum oil lotion products increased with increasing aloe gel contents. Products formulated with the undiluted or 50% aloe gels were most active and resolved inflammatory lesions faster than the standard product. The aloe gel alone showed minimal activity. Adverse effect was mild and tolerable. Conclusion: Aloe vera gel enhanced the anti-acne properties of Ocimum oil; the oil or its combination with aloe vera gel is more effective than 1% Clindamycin in the treatment of Acne vulgaris.