Age-related ten-year outcomes after percutaneous coronary intervention of in-stent restenosis

• DOI: 10.1016/j.ijcard.2025.133109
• Publication Date: 2025-03-07T04:19:33Z
• Authors: Constantin Kuna; Christian Bradaric; Tobias Koch; Antonia Presch; Felix Voll; Sebastian Kufner; Tareq Ibrahim; Heribert Schunkert; Karl-Ludwig Laugwitz; Salvatore Cassese; Adnan Kastrati; Jens Wiebe
• Keywords: Coronary restenosis

Highlights•The analysis addresses the lack of age-related long-term data after PCI DES-ISR.•10-year clinical outcomes 3511 patients were analyzed.•Long-term rates adverse events and mortality DES-ISR are high.•Older show a twofold risk cardiac death compared with younger patients.•Long-term TLR rate is lower in older than patients.AbstractBackgroundOlder often underrepresented trials investigating treatment coronary drug-eluting stent (DES) restenosis, but outcome urgently needed an ageing society. Thus, aim this observational, retrospective study was to close evidence.MethodsBetween January 2007 February 2021, 5497 in-stent restenosis (ISR) lesions treated at two large-volume centers Munich, Germany. We death, myocardial infarction (MI) repeat revascularization 1105 (31.5 %) 75 years 2406 (68.5 years. Survival analyzed using Kaplan-Meier method. Differences between groups tested log-rank test. Conventional multivariable adjustment for relevant variables performed.ResultsOlder more frequently female (30.1 % vs. 17.9 %, p < 0.001) presented less stable angina (67.8 72.0 0.001). After 10 years, 56.8 27.4 (HRadj, 2.45 [95 CI, 2.09–2.88], Accounting no difference found regarding MI while target lesion (TLR) occurred (24.2 33.7 %; HRadj, 0.77 0.66–0.89], 0.001).ConclusionsIn long-term, percutaneous intervention higher There MI.Graphical abstract