Delayed 68Ga-FAPI-46 PET/MR imaging confirms ongoing fibroblast activation in patients after acute myocardial infarction

• DOI: 10.1016/j.ijcha.2024.101340
• Publication Date: 2024-01-23T00:55:35Z
• Authors: Jana Kupusovic; Lukas Kessler; Sandra Kazek; Michal Kamil Chodyla; Lale Umutlu; Fadi Zarrad; Michael Nader; Wolfgang P. Fendler; Zohreh Varasteh; Ken Hermann; Dobromir Dobrev; Reza Wakili; Tienush Rassaf; Johannes Siebermair; Christoph Rischpler
• Keywords: 0301 basic medicine; Myocardial infarction; Original Paper; 03 medical and health sciences; Cardiovascular imaging; PET/MRI; RC666-701; Diseases of the circulatory (Cardiovascular) system; Acute coronary syndrome; FAPI; Fibroblast activation

Combined cardiac 68Ga-Fibroblast-Activation Protein-alpha inhibitor (FAPI) positron-emission tomography (PET) and magnetic resonance imaging (MRI) constitute a novel diagnostic tool in patients for the assessment of myocardial damage after an acute infarction (AMI). Purpose this pilot study was to evaluate simultaneous Ga-68-FAPI-46-PET/MR delayed phase AMI. Eleven underwent hybrid 68Ga-FAPI-46 PET/MRI post Standardized uptake values fibroblast activation volume (FAV) were calculated correlated with serum biomarkers MRI parameters. Significant could be demonstrated 11 (100 %) mean period 30.9 ± 22.0 days. FAV significantly exceeded size showed good correlation parameters as well damage. offers molecular morphological affected myocardium This demonstrates ongoing AMI generates hypotheses future studies while aiming better understanding remodeling following ischemic tissue