Potential mechanism of cell death in the developing rat brain induced by propofol anesthesia

• DOI: 10.1016/j.ijdevneu.2008.12.005
• Publication Date: 2008-12-28T09:59:29Z
• Authors: Vesna Pešić; Desanka Milanović; Nikola Tanić; Jelena Popić; Selma Kanazir; Vesna Jevtović‐To...; Sabera Ruždijić
• Keywords: Mechanism of Action

Abstract Commonly used general anesthetics can have adverse effects on the developing brain by triggering apoptotic neurodegeneration, as has been documented in rat. The rational of our study was to examine molecular mechanisms that contribute action propofol anesthesia 7‐day‐old (P7) rats. down‐regulation nerve growth factor (NGF) mRNA and protein expression cortex thalamus at defined time points between 1 24 h after treatment, well a decrease phosphorylated Akt were observed. extrinsic pathway induced over‐expression tumor necrosis (TNF) which led activation caspase‐3 both examined structures. Neurodegeneration confirmed Fluoro‐Jade B staining. Our findings provide direct experimental evidence anesthetic dose (25 mg/kg) induces complex changes are accompanied cell death rat brain.