Selective inhibition of metabotropic glutamate type 1 alpha receptor (mGluR1α) reduces cell proliferation and migration following status epilepticus in early development

• DOI: 10.1016/j.ijdevneu.2016.08.002
• Publication Date: 2016-08-13T07:06:12Z
• Authors: L.K. Friedman; A. Sharma; M. Corcia; T. Webster; L. Qazi; D. Simsovits; Y. Khalil; S. Hu; M. Kantrowitz; H. Hong
• Keywords: Alpha (finance)

The present study examined whether a single or multiple episode(s) of status epilepticus induced with kainic acid (KA) during the first 3 weeks postnatal (P) development would aberrantly stimulate proliferation zones that alters migration to potentially injured areas and they be blocked by selective Group I mGluR antagonists. mGluR1α (LY367385) mGluR5 (MPEP) antagonists were administered 2h following KA-induced animals after 7days. Proliferating cells subventricular zone (SVZ), third ventricle, hippocampus, amygdala cortical complex analyzed proliferative marker, Ki67; two complementary retrograde dye tracers. Proliferation increased in extrahippocampal limbic structures when KA was on P13 P20 which correlated number at older age. LY367385 post-treatment caused striking decreases all presence absence injury, whereas reduction MPEP observed only within (Amg/ERcx) seizures (3×KA). After 3×KA post-treatments, diminished co-staining tracers Ki67 Amg/ERcx despite high levels progenitors marked this region. This indicates not local SVZ distant inhibited, but also itself reduced indirectly since there less migrate from SVZ. Co-labeling biomarkers provided evidence for neuronal differentiation suggesting potential aberrant integration may occur locations, targeting receptors therapeutic strategy future development.