Prevalence of drug resistant tuberculosis in patients presenting with a large pericardial effusion at King Edward VIII Hospital

• DOI: 10.1016/j.ijid.2014.03.611
• Publication Date: 2014-05-27T17:15:58Z
• Authors: N.P. Magula; N.D. Madala; Y. Kriel; V. Bayi; N.P. Duze; T.C. Manzini; R. Matshela; D.P. Naidoo; B.M. Mayosi
• Keywords: Pericardiocentesis; Tuberculous Pericarditis; Pericardial fluid

Background: Tuberculosis (TB) accounts for 70% of pericardial effusions in sub-Saharan Africa. There is a high burden drug resistant TB South Africa, with an estimated 4600 new cases identified 2012, but its frequency patients unknown. The aim this study was to determine the prevalence tuberculosis admitted King Edward VIII hospital effusion. Methods & Materials: This cross sectional participants enrolled Investigation Management Pericarditis (IMPI) from October 2009 August 2013. Enrolled were adults clinical diagnosis pericarditis. Diagnostic and therapeutic pericardiocentesis preformed where suitable. Biochemistry, microscopy, liquid culture (MGIT 960), line probe assay, direct sensitivity testing cytology performed. Results: A total 163 enrolled, 129 (79.6%) whom HIV infected. Pericardiocentesis performed 100 (64%) diagnostic tests 78 these. Acid fast bacilli observed 10/75 (13.3%) using Auramine stain 23/78 (29.5%) positive (3/78 samples not suitable stain). Where acid observed, either by smear microscopy or culture, assay Mycobacterium complex 21/24 (87.5%); 2/21 (9.5%) isolates isoniazid rifampicin (MDR-TB) 1 2 also streptomycin, ofloxacin kanamycin (XDR-TB). No found have co-infections malignancy. Conclusion: Drug present nearly 10% finding TB, isolated only space, underscores importance presumed