Seasonal drivers of WHO defined fast breathing pneumonia - impact of viral activity in the nasopharyngeal niche’

• DOI: 10.1016/j.ijid.2016.02.917
• Publication Date: 2016-03-29T02:04:58Z
• Authors: S. Kerai; B. Baloch; I. Nisar; N. Brown; F. Aziz; F. Jehan
• Keywords: Rhinovirus; Human bocavirus; Common cold; Carriage

Background: The association between nasopharyngeal carriage of viruses and mild to moderate lower respiratory tract infections is poorly understood. We explore this in an ongoing trial fast breathing pneumonia with objective estimate the proportions viral children Methods & Materials: study being conducted two primary health care centers low income communities located Karachi, Pakistan. Children 2 59 months old identified have cough tachypnea defined by WHO without danger signs other illness like T.B., asthma, enteric are included. Viral carriages assessed taking swabs analyzed using LUMINEX xTAG Respiratory Panel assay. data has been collected for period from September 2014 August 2015. Results: About 2126 (20%) our community, who presented symptoms at center, tachypnic. From these, 1055 enrolled, results available on 712 children. Rhinovirus detected 49% children, followed Syncytial Virus (RSV) 6%, Human Metapnuemovirus 5% Bocavirus Adenovirus 3% cases. ParaInfluenza type III was 7% IV while rest targets found ≤ 2% peak be corresponding increased presentation October January suggesting a positive epidemiological association. rise Metapneumovirus can seen during early summer May RSV late (August October) episodes pneumonia. parainfluenza coincides February Parainfluenza December, March which seems follow conventional seasonality pattern Seasonal Seasonality Conclusion: variation detection virus among indicating their possible role pathogenesis disease. This makes case exploring antibiotics conducting studies rates controls.