Prodromal fever indicates a high risk of liver failure in acute hepatitis B

• DOI: 10.1016/j.ijid.2017.02.009
• Publication Date: 2017-02-21T05:33:51Z
• Authors: Wen-Jun Du; Li Liu; Chao Sun; Jin-Hong Yu; Di Xiao; Qiang Li
• Keywords: HBeAg

The role of prodromal fever in the clinical course acute hepatitis B virus (HBV) infection is still largely unclear. This study was conducted to investigate factors associated with and its development liver failure (ALF) patients (AHB).Inpatients AHB diagnosed between January 2006 December 2010 were evaluated followed. Clinical manifestations, results laboratory tests, outcomes compared without fever. diagnosis based on discrete onset symptoms, jaundice, abnormal function detection high-titer IgM antibody core antigen (anti-HBc), a compatible history.A total 618 inpatients identified during period, whom 102 (16.5%) had 41 (6.6%) developed ALF. Prodromal indicated more severe injury independently e (HBeAg) negativity. occurrence ALF common febrile than non-febrile (18.6% vs. 4.3%, p<0.001). Multivariate logistic regression showed temperature >38.0°C be risk ALF, an odds ratio (95% confidence interval) 3.5 (1.4-8.6) 7.1 (2.6-19.7), respectively.AHB fever, which lack HBeAg due HBV mutation, are at high Febrile should managed particular care.