Serotype and genotype diversity of dengue viruses circulating in India: a multi-centre retrospective study involving the Virus Research Diagnostic Laboratory Network in 2018

• DOI: 10.1016/j.ijid.2021.08.045
• Publication Date: 2021-08-21T14:52:53Z
• Authors: K. Alagarasu; J.A. Patil; M.B. Kakade; A.M. More; B. Yogesh; P. Newase; S.M. Jadhav; D. Parashar; H. Kaur; N. Gupta; N. Vijay; J. Narayan; P.S. Shah; Dr Ajanta Sharma; Dr Amita Jain; Dr Anudita Bhargava; Dr B. Anukumar; Dr Ashok M; Dr Bharti Malhotra; Dr B.J. Borkakoty; Dr Debasis Biswas; Dr SC Jaryal; Dr Kanwardeep Sin...; Dr K. Kaveri; Dr P.K. Khatri; Dr Manoj Kumar; Dr K. Nagamani; Dr Rahul Dhodapkar; Dr Rupinder Bakshi; Dr Paramjeet S. Gill; Dr Sanghamitra Pati; Dr Shanta Dutta; Dr Shantala G; Dr Usha Kalawat; Dr Disha A. Patel; Dr P. Vijayachari
• Keywords: Molecular Epidemiology

A retrospective study was undertaken to investigate the circulating dengue virus (DENV) serotypes and genotypes in India 2018.In total, 4963 samples referred research diagnostic laboratories (n=21), Indian Council of Medical Research-National Institute Virology (ICMR-NIV) ICMR-NIV field units (n=2) for diagnosis 2018 were tested using a real-time reverse transcription polymerase chain reaction assay presence DENV serotypes. Representative sequenced envelope (E) gene.Regional diversity observed with regard dominant DENV-2 found be most common serotype many states. Thrombocytopenia, petechiae malaise associated infection. Phylogenetic analyses E gene sequences revealed circulation I V DENV-1, two lineages genotype IV, DENV-3 III DENV-4 I.This regional differences prevalence India, provides baseline data continuous molecular surveillance. Molecular surveillance may have implications predicting large-scale outbreaks if shifts predominantly are detected during early phase season.