Alterations of gut microbiota in patients with active pulmonary tuberculosis in China: a pilot study

• DOI: 10.1016/j.ijid.2021.08.064
• Publication Date: 2021-09-03T05:39:35Z
• Authors: Wenpei Shi; Yi Hu; Zhu Ning; Fan Xia; Meiying Wu; Yue O.O. Hu; Cheng Chen; Stefanie Prast-Ni...; Biao Xu
• Keywords: Lachnospiraceae

Background: The aim of this study was to identify the differences in diversity, composition, and function gut microbiota between tuberculosis (TB) patients healthy controls (HCs).Methods: A cross-sectional conducted three cities China. Stool samples from 94 treatment-naive TB 62 HCs were analyzed by 16S rRNA gene sequencing. further divided into antibiotic-free antibiotic-exposure according their use non-specific antibiotics before diagnosis.Results: Compared with HCs, presented a different microbial community (P < 0.005) decreased Shannon diversity 0.005). Among patients, relative abundances short-chain fatty acid (SCFA)-producing genera such as Lachnospiraceae ND3007 group (log2(FC) = −2.74) lower, while several conditional pathogen-related Enterococcus 12.05) Rothia 6.322) at higher levels. In addition, 41% received diagnosis. Antibiotic exposure correlated an additional reduction α depletion SCFA-producing bacteria. Microbial functional analysis revealed that biosynthesis capacity amino acids lower among compared HCs.Conclusions: Significant alterations composition metabolic pathways observed. could alter which should be considered anti-TB treatment.