Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry

• DOI: 10.1016/j.ijid.2022.01.016
• Publication Date: 2022-01-19T23:27:34Z
• Authors: Daniella Nunes Pe...; Leticia Ferreira ...; Milena Maria More...; Carísi Anne Polan...; Aline Gabrielle S...; André Soares de M...; Barbara Lopes Farace; Christiane Corrêa...; Cíntia Alcantara ...; Daniela Ponce; Eliane Würdig Roesch; Euler Roberto Fer...; Fernanda Barbosa ...; Fernanda d'Athayd...; Fernando Anschau; Fernando Graça Ar...; Frederico Bartolazzi; Giovanna Grunewal...; Guilherme Fagunde...; Helena Duani; Heloisa Reniers V...; Henrique Cerqueir...; Jamille Hemétrio ...; Joanna d'Arc Lyra...; Joice Coutinho de...; José Miguel Chatkin; Júlia Drumond Par...; Juliana Machado-R...; Karen Brasil Ruschel; Lílian Santos Pin...; Luanna Silva Mont...; Luciana Siuves Fe...; Luciane Kopittke; Luís César de Castro; Luiz Antônio Nasi; Máderson Alvares ...; Maiara Anschau Fl...; Maíra Dias Souza; Marcelo Carneiro; Maria Aparecida C...; Mariana Frizzo de...; Matheus Carvalho ...; Milton Henriques ...; Natália da Cunha ...; Neimy Ramos de Ol...; Pedro Ledic Assaf; Renan Goulart Finger; Roberta Xavier Ca...; Rochele Mosmann M...; Saionara Cristina...; Samuel Penchel Al...; Silvana Mangeon M...; Silvia Ferreira A...; Talita Fischer Ol...; Thulio Henrique O...; Yuri Carlotto Ram...; Evelin Paola de A...; Thainara Conceiçã...; Alexandre Vargas ...; Patricia Klarmann...; Roberta Pozza; Caroline Scherer ...; Magda Carvalho Pires; Milena Soriano Ma...
• Keywords: Epidemiology; SARS-CoV-2; 610; COVID-19; Infectious and parasitic diseases; RC109-216; Prognosis; Article; 3. Good health; 03 medical and health sciences; COVID-19 Testing; 0302 clinical medicine; Hypothyroidism; Humans; Female; Hospital Mortality; Registries; Mortality; Aged

It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19.The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis.Of 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in patients with hypothyroid (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs 27.0%; p=0.062).Patients with hypothyroidism had a lower requirement of mechanical ventilation and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.