Impact of Bacterial Phenotypic Variation with Bacteriophage therapy: A Pilot Study with Prosthetic Joint Infection Isolates

• DOI: 10.1016/j.ijid.2022.03.022
• Publication Date: 2022-03-21T17:23:14Z
• Authors: James B. Doub; Ken Urish; Martin Lee; Joseph Fackler
• Keywords: Lytic cycle; Teichoic acid; Phage therapy; Arthrocentesis

Given the specificity of bacteriophage attachment receptors, a single bacterial isolate is currently utilized to match therapeutic, thereby extrapolating activity all bacteria in vivo. Consistently, main receptor for Staphylococcus aureus teichoic acid, and it known that this has phenotypic variations different vivo environments. Consequently, aim study was determine whether similar across prosthetic joint infection environments.Three patients with infections who had S. grow from arthrocentesis cultures at least three deep tissue were analyzed growth inhibition library 56 bacteriophages.Discordant seen Furthermore, bacteriophages most robust lytic potential isolates usually did not demonstrate corresponding clinical isolates.Variations can occur between environments, which likely secondary glycosylation patterns acid. if discordant present, retreating have needed effective, reproducible outcomes.