Clinical and laboratory profiles of the SARS-CoV-2 Delta variant compared with pre-Delta variants

• DOI: 10.1016/j.ijid.2022.04.050
• Publication Date: 2022-04-26T15:58:17Z
• Authors: Shivang Bhakta; Devang K. Sanghavi; Patrick W. Johnson; Katie L. Kunze; Matthew R. Neville; Hani M. Wadei; Wendelyn Bosch; Rickey E. Carter; Sadia Z. Shah; Benjamin D. Pollock; Sven P. Oman; Leigh Speicher; Jason Siegel; Claudia R. Libertin; Mark W. Matson; Pablo Moreno Franco; Jennifer B. Cowart
• Keywords: Prothrombin time

The emergence of SARS-CoV-2 variants concern has led to significant phenotypical changes in transmissibility, virulence, and public health measures. Our study used clinical data compare characteristics between a Delta variant wave pre-Delta hospitalized patients.This single-center retrospective defined as an increasing number COVID-19 hospitalizations, which peaked later decreased. Data from the United States Department Health Human Services were identify waves' primary variant. Wave 1 (August 8, 2020-April 1, 2021) was characterized by heterogeneous variants, whereas 2 (June 26, 2021-October 18, predominantly Descriptive statistics, regression techniques, machine learning approaches supported comparisons waves.From cohort (N = 1318), patients (n 665) more likely be younger, have fewer comorbidities, require care intensive unit, show inflammatory profile with higher C-reactive protein, lactate dehydrogenase, ferritin, fibrinogen, prothrombin time, activated thromboplastin international normalized ratio compared 653). gradient boosting model showed area under receiver operating characteristic curve 0.854 (sensitivity 86.4%; specificity 61.5%; positive predictive value 73.8%; negative 78.3%).Clinical laboratory can estimate regardless genomic testing availability. This finding implications for variant-driven treatment protocols further research.