Comparison between a rapid diagnostic test and dried blood spot-based immunoassay for hepatitis B surface antigen testing: Performance and cost implications in a population-based serosurvey in Vietnam

• DOI: 10.1016/j.ijid.2022.10.011
• Publication Date: 2022-10-12T08:46:14Z
• Authors: Sumiyo Okawa; Kenichi Komada; Yasunori Ichimura; Masaya Sugiyama; Hung Thai Do; Huy Xuan Le; Thanh Tien Hoang; Trieu Bao Nguyen; Mai Kim Huynh; Hang Thi Hai Hoang; Nhu Anh Thi Tran; Thieu Hoang Le; Quyet Thi Ngo; Shinsuke Miyano; Yuta Yokobori; Yosuke Inoue; Tetsuya Mizoue; Masahiko Hachiya
• Keywords: Dried blood spot; Kappa; Hepatitis B; Rapid diagnostic test

This study aimed to determine the agreement between a rapid diagnostic test (RDT) and dried blood spot (DBS)-based electrochemiluminescence immunoassay (ECLIA) of hepatitis B surface antigen compare costs conducting serosurveys using RDTs DBS in field setting.A serosurvey was conducted South Central Coast region Vietnam May 2019. Participants aged 1-39 years were recruited four-stage random sampling method tested for an RDT kit (Alere Determine) DBS-based ECLIA. The ECLIA assessed cross-tabulation Cohen kappa. Cost data categorized by input (personnel, transportation, consumables, laboratory capital item/overhead) survey phase (survey preparation, data/biospecimen collection, testing, coordination).A total 2072 participants analyzed. There 99% results, with kappa 0.9. estimated cost UD $75,291, whereas $53,182.RDTs provide results high agreements. are better option terms cost, may be useful when evaluating multiple infectious diseases.