IN VIVO ANTI-DENGUE STUDY OF SCHIZOPHYLLUM COMMUNE AQUEOUS EXTRACT IN AG129 MICE

• DOI: 10.1016/j.ijid.2023.04.156
• Publication Date: 2023-05-18T17:43:22Z
• Authors: K. Ellan; M.R.Mohd Abd. Razak; A. Muhammad; N.H. Jelas; M. Farhan; E. Tiagaraj; S.K. Yee; V. Jicob; Z. Zawawi; M.Z. Wahid; M.A. Azizan; J. Kalyanasundram; A. Adiee; A. Zulkapli; W.M.A.A. Zainuzzaman; N. Bahrin; M. Mayasari; J. Lee; P. Patrick; C. Keong; R. Mohd Zain; A.F. Mohamed; V. Sabaratnam; R. Thayan; K. Kamel
• Keywords: Schizophyllum commune

tralising antibodies by surrogate virus neutralization test (sVNT) and plaque reduction (PRNT).Findings: Among the 1,736 HCWs enrolled in our cohort, 252 provided pre-and post-vaccination blood samples after each dose of either vaccine.Two doses BNT162b2 generated levels neutralizing (sVNT inhibition = 96.8%,range 42.8%,98.2%) comparable to those natural infections first wave 84.0%,range 32.9%,93.8%).Similar were achieved with three CoronaVac 95.3%, range 64.7%,98.3%) heterologous vaccination two followed a booster vaccine 97.0%,range 85.8%, 97.7%).These antibody waned faster second slower third for both vaccines. Conclusion:The vaccines can generate robust responses infections.Three vaccine, or boost following Coro-naVac are required achieve similar neutralising vaccinees who received vaccine.