Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort study

• DOI: 10.1016/j.ijid.2023.06.008
• Publication Date: 2023-06-28T18:55:44Z
• Authors: Patrick O. Campbell; Kate Gallagher; Simon C. Dalton; Sarah C.L. Metcalf; Nicholas M. Douglas; Stephen T. Chambers
• Keywords: Infective Endocarditis

We examined the safety and clinical outcomes of outpatient parenteral antibiotic therapy (OPAT) for patients with infective endocarditis (IE) in Christchurch, New Zealand.Demographic data were collected from all adult treated IE over 5 years. Outcomes stratified by receipt at least partial OPAT vs entirely hospital-based therapy.There 172 episodes between 2014 2018. was administered 115 cases (67%) a median 27 days after 12 inpatient treatment. In cohort, viridans group streptococci commonest causative pathogens (35%) followed Staphylococcus aureus (25%) Enterococcus faecalis (11%). There six (5%) antibiotic-related adverse events 26 (23%) readmissions treatment group. Mortality 6% (7/115) 6 months 10% (11/114) 1 year receiving wholly 56% (31/56) 58% (33/56), respectively. Three (3%) had relapse during 1-year follow-up period.OPAT can be used safely IE, even selected complicated or difficult-to-treat infections.