CD101 as an indicator molecule for pathological changes at the interface of host-microbiota interactions

• DOI: 10.1016/j.ijmm.2021.151497
• Publication Date: 2021-03-20T23:39:20Z
• Authors: Marius Wrage; Johanna Kaltwasser; Sonja Menge; Jochen Mattner
• Keywords: Dysbiosis; Intraepithelial lymphocyte; Mucosal immunology

Intestinal microbiota signal to local and distant tissues in the body. Thus, they also regulate biochemical, metabolic immunological processes gut pancreas. Vice versa, eating habits or immune system of host shape intraluminal microbiota. Disruptions these versatile host-microbiota interactions underlie pathogenesis complex immune-mediated disorders such as inflammatory bowel disease (IBD) type 1 diabetes (T1D). Consequently, dysbiosis increased intestinal permeability associated with both change biology underlying tissues, evidenced, for example, by an altered expression surface markers CD101 on cells located at dynamic interfaces. CD101, a heavily glycosylated member immunoglobulin superfamiliy, is predominantly detected myeloid cells, intraepithelial lymphocytes (IELs) regulatory T (Tregs) gut. The protects from experimental enterocolitis T1D. improved outcome diseases anti-inflammatory cytokine profile reduced expansion cells. However, distinct bacteria suppress similar does inflammation T1D IBD patients might be consequence composition microbiota, enhanced bacterial translocation subsequent primining systemic responses.