Norovirus gastroenteritis in children under-five years hospitalized for diarrhea in two cities of northeast India: A retrospective study

• DOI: 10.1016/j.ijmmb.2023.100397
• Publication Date: 2023-06-10T14:16:26Z
• Authors: Biswajyoti Borkakoty; Nargis K. Bali; Aniruddha Jakaria; Rahul Hazarika; T. Temsu; Munmun Gohain; Harpreet Kaur
• Keywords: Sapovirus; Astrovirus; Acute gastroenteritis

Norovirus gastroenteritis, known to cause 'winter vomiting disease' is increasingly being identified as a major of viral gastroenteritis worldwide. The impact and prevalence this disease are lacking in many parts India including northeast India. This study aimed determine the association norovirus among under-five-year-old hospitalized children two cities (Dibrugarh Assam & Dimapur Nagaland).A retrospective analysis 407 randomly selected diarrheal stool samples was conducted using commercial multiplex probed-based real-time RT-PCR assay capable detecting six-viral pathogens GI, GII, Rotavirus, Human Adenovirus, Astrovirus, Sapovirus.Results showed that detected 18.4% (75/407; 95% CI: 14.8%-22.5%), with genogroup II predominant group 97.3% cases. A significant diarrhea found seasonality, higher colder months compared warmer (22.4% vs 9.1%, p-value:0.002). Additionally, 66.7% (50/75) cases had reported symptom shorter duration (p-value 0.03). Co-infections other were seen 45.9% (187/407) detection rotavirus 67.1% (273/407), human adenovirus (45.9%; 187/407), sapovirus astrovirus (5.9%, 24/407 each), GI (0.5%, 2/407) cases.This reports further highlights responsible for substantial hospitalization under-five years region.