Relationship between maternal Group B Streptococcal colonization and gestational vaginal microbiome composition: A pilot study

• DOI: 10.1016/j.ijmmb.2023.100426
• Publication Date: 2023-07-12T17:43:38Z
• Authors: Tan Minh Le; Yeseul Choi; Hong Duc Thi Nguyen; Donghyeon Lee; Olive EM. Lee; Gun Oh Chong; Won Joon Seong; Hyun-Hwa Cha; Hyung Soo Han
• Keywords: Group B; Dysbiosis

Group B Streptococcus (GBS) colonization and vaginal microbiome (VMB) dysbiosis are associated with adverse perinatal outcomes. However, the role of GBS in maternal VMB remains unclear. Herein, we aimed to investigate this relationship identify additional pathogens for potential implications understanding their clinical significance.Vaginal swab samples were obtained before delivery from nine women normal pregnancies detection 16S rRNA gene sequencing. The diversity analysis community state types clustering used compare GBS-positive vs. GBS-negative groups. ANCOM-BC was implemented differentially abundant microbes (DAMs) colonization. correlation receiver operating characteristic evaluate between DMAs parameters.There 6/9 (66,7%) pregnant women. α-diversity index (p ​= ​0.71 observed operational taxonomic units p ​0.90 Shannon diversity), β-diversity ​0.583), ​0.23) not significantly different -negative Four DAMs, namely, Actinomyces, Shigella, Fenollaria, Gemella, colonization, reflecting dynamicity gestational VMB. Their abundances negatively correlated birth weight had acceptable discriminating ability premature membrane rupture (area under curve, 0.9).Despite absence significant effects on overall composition, our preliminary results investigated that related high abundance four utility as microbial signatures.