Advances in electrochemical detection of B-type natriuretic peptide as a heart failure biomarker

• DOI: 10.1016/j.ijoes.2024.100748
• Publication Date: 2024-08-02T09:41:48Z
• Authors: Yanjun Li; Haitao Xu; Shuang Chen; Jiazi Wang
• Keywords: Risk Stratification

Heart failure (HF) is a global health crisis with an increasing prevalence, emphasizing the urgent need for effective diagnostic and monitoring strategies. B-type natriuretic peptide (BNP), sensitive specific biomarker, has revolutionized HF management by enabling early detection, risk stratification, treatment guidance. However, conventional methods BNP detection face limitations in sensitivity, specificity, real-time capabilities. Electrochemical biosensors have emerged as promising alternative, combining specificity of biological recognition elements sensitivity electrochemical transduction. This review explores principles, advancements, challenges development detection. Innovative biorecognition elements, signal amplification techniques, nanomaterial-based electrode modifications significantly improved analytical performance these biosensors, achieving impressive limits direct measurements complex samples. Furthermore, integration microfluidic platforms wearable/implantable devices opened new avenues continuous, levels, facilitating personalized precise interventions management.