The impact of antiphospholipid antibodies in children with lupus nephritis

• DOI: 10.1016/j.ijpam.2015.08.002
• Publication Date: 2015-11-22T05:29:04Z
• Authors: Sulaiman M. Al-Ma...; Alhanouf AlSaleem; Turki Al-Hussain; Abdullah Al Sonbul; Hadeel AlMana
• Keywords: Nephritis

Background and objectives: To evaluate the frequency of antiphospholipid anti-bodies (APLa) among patients with childhood lupus nephritis (cLN) to assess their impact on long-term renal outcomes. Design setting: This is an observational hospital based study. Patients methods: cLN diagnosed by biopsy seen between January 2002 June 2014 were included. APLa positivity was defined if detection positive 2 occa-sions 6-12 weeks apart during follow up. Demographic features, age at disease onset, duration, follow-up duration clinical laboratory variables time collected. The reviewed for class, microthrombi, activity chronicity indices. Renal outcome measures included serum creatinine levels, protein/creatinine ratio end stage (ESRD). Results: Fifty-nine, (49 female) a mean 19.8 years dura-tion 6.8 involved. detected in 46 (78%) patients. Twenty-two had class IV nephritis, which more prevalent frequencies III V similar 10 each (7 APLa). presence did not correlate or Microthrombosis found patients, 8 them APLa. higher elevated hypertension, 9 developed ESRD, 7 There no statistically significant association accrual damage index manifestations. Furthermore, there be-tween other autoantibodies. Conclusion: high. While significant, tend develop microthrombi are probably risk ESRD.