Multicentric Assessment of Safety and Efficacy of Combinatorial Adjuvant Brain Metastasis Treatment by Intraoperative Radiation Therapy and Immunotherapy

• DOI: 10.1016/j.ijrobp.2024.01.009
• Publication Date: 2024-01-09T01:19:53Z
• Authors: Julian P. Layer; Ehab Shiban; Stefanie Brehmer; Christian D. Diehl; Douglas Guedes de...; Motaz Hamed; Cas S. Dejonckheere; Daniel T. Cifarelli; Lea L. Friker; Ulrich Herrlinger; Michael Hölzel; Hartmut Vatter; Matthias Schneider; Stephanie E. Combs; Leonard Christoph...; Christopher P. Ci...; Frank A. Giordano; Gustavo R. Sarria; Klaus-Henning Kahl
• Keywords: Intraoperative radiation therapy; Wound dehiscence

After surgical resection of brain metastases (BMs), intraoperative radiation therapy (IORT) provides a promising alternative to adjuvant external beam by enabling superior organ-at-risk preservation, reduction in-hospital times, and timely admission subsequent systemic treatments, which increasingly comprise novel targeted immunotherapeutic approaches. We sought assess the safety efficacy IORT in combination with immune checkpoint inhibitors (ICIs) other therapies (TTs).