Molecular evolution, virology and spatial distribution of HCV genotypes in Pakistan: A meta-analysis

• DOI: 10.1016/j.imj.2023.11.007
• Publication Date: 2023-11-18T16:33:49Z
• Authors: Arslan Habib; Nadiya Habib; Khalid Mahmood Anjum; Riffat Iqbal; Zeeshan Ashraf; Muhammad Usman Taj; Muhammad Asim; Kanwal Javid; Faezeh Idoon; Saeid Dashti; Cassio Rocha Mede...; Ana Pavla Almeida...; Henrique Douglas ...
• Keywords: Molecular Epidemiology; Hepatitis C

Hepatitis C, caused by the C Virus (HCV), is second most common form of viral hepatitis. The geographical distribution HCV genotypes can be quite complex, making it challenging to ascertain prevalent genotype in a specific area. To address this, review was conducted determine prevalence across various provinces and as whole Pakistan. scientific literature regarding prevalence, distribution, genotyping, epidemiology gathered from published articles spanning years 1996 2020. Genotype 1 accounted for 5.1% patients, with its predominant subtype being 1a at 4.38%. frequencies other subtypes, 1b 1c, were observed 1.0% 0.31% respectively. 2 had frequency 2.66%, widely distributed 2a 2.11% patients. Its 2b 2c, 0.17% 0.36% among all isolates 3 (65.35%), frequent 3a (55.15%), followed 3b (7.18%). 4, 5, 6 scarce Pakistan, 0.97%, 0.08%, 0.32% untypeable mixed 21.34% 3.53% Estimating proves productive method assisting duration selection antiviral treatment. Different exhibit variations their response treatments. may have distinct natural histories, including disease progression severity. Some lead more rapid liver damage, while others progress slowly. This information guide screening testing strategies, helping identify individuals higher risk developing severe complications. Studying population provide valuable insights into transmission dynamics virus.