Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells

• DOI: 10.1016/j.immuni.2024.06.015
• Publication Date: 2024-07-23T15:18:49Z
• Authors: Malte Simon; Philipp Stüve; Lisa Schmidleithner; Sebastian Bittner; Niklas Beumer; Nicholas Strieder; Christian Schmidl; Asmita Pant; Claudia Gebhard; Andreas Eigenberger; Michael Rehli; Lukas Prantl; Thomas Hehlgans; Benedikt Brors; Charles D. Imbusch; Michael Delacher; Markus Feuerer

Tissue adaptation is required for regulatory T (Treg) cell function within organs. Whether this program shares aspects with other tissue-localized immune populations unclear. Here, we analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45